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desvenlafaxine will improve the degree or result of codeine by affecting hepatic enzyme CYP2D6 metabolism. Use Caution/Observe. Desvenlafaxine inhibits CYP2D6; with larger desvenlafaxine doses (ie, 400 mg) minimize the CYP2D6 substrate dose by around 50%; no dosage adjustment desired with desvenlafaxine doses seven consecutive days straight away ah